Exposure to Metalworking Fluids and Cancer Incidence in the United Auto Workers-General Motors Cohort.

ABSTRACT: In previous studies, investigators have reported increased risks of specific cancers associated with exposure to metalworking fluids (MWFs). In this report we broadly examine the incidence of 14 types of cancer, with a focus on digestive, respiratory, and hormonal cancers, in the United Auto Workers-General Motors (UAW-GM) cohort, a cohort of workers exposed to MWFs (1973-2015). The cohort included 39,132 workers followed for cancer incidence. Cox models yielded estimates of adjusted hazard ratios, with categorical variables for lagged cumulative exposure to 3 types of MWF (straight, soluble, and synthetic). We fitted penalized splines to examine the shape of the exposure-response relationships. There were 7,809 incident cancer cases of interest. Oil-based straight and soluble MWFs were ea

SUBMITTER: Colbeth HL 

PROVIDER: S-EPMC10310982 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature