Efficacy and safety of subcutaneous immunotherapy in asthmatic children allergic to house dust mite: a meta-analysis and systematic review.

ABSTRACT:

Background

Subcutaneous immunotherapy (SCIT) has been proved to be effective and safe in adult asthma. But it is still controversial in children.

Object

To evaluate the efficacy and safety of SCIT in asthmatic children with allergy to house dust mite.

Method

We searched the databases of Cochrane Library, EMBASE and MEDLINE (from 1 January 1990 to 1 December 2022). Two reviewers independently screened studies, extracted data and critically appraised the risk of bias. We used the Revman 5 to synthesize the effect sizes.

Results

We finally selected 38 eligible studies including 21 randomized controlled trials to evaluate the efficacy and safety of SCIT and 17 observational studies to assess the safety. The results revealed that short-term asthma symptom scores wer

SUBMITTER: Zheng C 

PROVIDER: S-EPMC10310999 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature