Transcriptome analysis of CD4⁺ T cells from HIV-infected individuals receiving ART with LLV revealed novel transcription factors regulating HIV-1 promoter activity.

ABSTRACT: Some HIV-infected individuals receiving ART develop low-level viremia (LLV), with a plasma viral load of 50-1000 copies/mL. Persistent low-level viremia is associated with subsequent virologic failure. The peripheral blood CD4⁺ T cell pool is a source of LLV. However, the intrinsic characteristics of CD4⁺ T cells in LLV which may contribute to low-level viremia are largely unknown. We analyzed the transcriptome profiling of peripheral blood CD4⁺ T cells from healthy controls (HC) and HIV-infected patients receiving ART with either virologic suppression (VS) or LLV. To identify pathways potentially responding to increasing viral loads from HC to VS and to LLV, KEGG pathways of differentially expressed genes (DEGs) were acquired by comparing VS with HC (VS-HC

SUBMITTER: Chen J 

PROVIDER: S-EPMC10311176 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature