Novel radiomic analysis on bi-parametric MRI for characterizing differences between MR non-visible and visible clinically significant prostate cancer.

ABSTRACT:

Background

around one third of clinically significant prostate cancer (CsPCa) foci are reported to be MRI non-visible (MRI─).

Objective

To quantify the differences between MR visible (MRI+) and MRI^─ CsPCa using intra- and peri-lesional radiomic features on bi-parametric MRI (bpMRI).

Methods

This retrospective and multi-institutional study comprised 164 patients with pre-biopsy 3T prostate multi-parametric MRI from 2014 to 2017. The MRI^─ CsPCa referred to lesions with PI-RADS v2 score < 3 but ISUP grade group > 1. Three experienced radiologists were involved in annotating lesions and PI-RADS assignment. The validation set (D_v) comprised 52 patients from a single institution, the remaining 112 patients were used for training (D_t

SUBMITTER: Li L 

PROVIDER: S-EPMC10311200 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature