3C^pro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation.

ABSTRACT: Foot-and-mouth disease virus (FMDV) has developed various strategies to antagonize the host innate immunity. FMDV L^pro and 3C^pro interfere with type I IFNs through different mechanisms. The structural protein VP3 of FMDV degrades Janus kinase 1 to suppress IFN-γ signaling transduction. Whether non-structural proteins of FMDV are involved in restraining type II IFN signaling pathways is unknown. In this study, it was shown that FMDV replication was resistant to IFN-γ treatment after the infection was established and FMDV inhibited type II IFN induced expression of IFN-γ-stimulated genes (ISGs). We also showed for the first time that FMDV non-structural protein 3C antagonized IFN-γ-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation. 3C^pro

SUBMITTER: Wu X 

PROVIDER: S-EPMC10311264 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature