Supervised biological network alignment with graph neural networks.

ABSTRACT:

Motivation

Despite the advances in sequencing technology, massive proteins with known sequences remain functionally unannotated. Biological network alignment (NA), which aims to find the node correspondence between species' protein-protein interaction (PPI) networks, has been a popular strategy to uncover missing annotations by transferring functional knowledge across species. Traditional NA methods assumed that topologically similar proteins in PPIs are functionally similar. However, it was recently reported that functionally unrelated proteins can be as topologically similar as functionally related pairs, and a new data-driven or supervised NA paradigm has been proposed, which uses protein function data to discern which topological features correspond to functional relatedness.

SUBMITTER: Ding K 

PROVIDER: S-EPMC10311300 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature