Bakdrive: identifying a minimum set of bacterial species driving interactions across multiple microbial communities.

ABSTRACT:

Motivation

Interactions among microbes within microbial communities have been shown to play crucial roles in human health. In spite of recent progress, low-level knowledge of bacteria driving microbial interactions within microbiomes remains unknown, limiting our ability to fully decipher and control microbial communities.

Results

We present a novel approach for identifying species driving interactions within microbiomes. Bakdrive infers ecological networks of given metagenomic sequencing samples and identifies minimum sets of driver species (MDS) using control theory. Bakdrive has three key innovations in this space: (i) it leverages inherent information from metagenomic sequencing samples to identify driver species, (ii) it explicitly takes host-specific variation into con

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10311314 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature