Biomimetic Sequence-Templating Approach toward a Multiscale Modulation of Chromogenic Polymer Properties.

ABSTRACT: Precision control via molecular structure over adaptive conjugated polymer properties in aqueous environments is critical for realizing their biomedical applications. Here, we unravel the dependence of amphiphilic peptide-polydiacetylene (PDA) conjugate properties on the characteristic steric and hydrophobic contributions within peptide segments that serve as a biomimetic template for diacetylene polymerization in water. We investigated the functional impacts of molecular volume and polarity changes brought by dipeptide substitution domains on the following peptide-PDA material properties at multiple length scales: supramolecular assembly behavior, chain conformation-dependent photophysical properties, cell-material interfacing, and for the first time, bulk electrical properties of their f

SUBMITTER: Kuang Y 

PROVIDER: S-EPMC10311629 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature