Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK.

ABSTRACT: In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study aims to explore the association between vaccination with live oral rotavirus vaccines and IBD development. A population-based cohort study was used, analysing primary care data from the Clinical Practice Research Datalink Aurum. Participants included children born in the UK from 2010 to 2015, followed from a minimum of 6 months old to a maximum of 7 years old. The primary outcome was IBD, and the primary exposure was rotavirus vaccination. Cox regression analysis with random intercepts for general

SUBMITTER: Flatt A 

PROVIDER: S-EPMC10311680 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature