The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease.

ABSTRACT: Despite the increasing demographic diversity of the United States' aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease (AD). Most autopsy-based studies have focused on cohorts of non-Hispanic White decedents (NHWD), with few studies including Hispanic decedents (HD). We aimed to characterize the neuropathologic landscape of AD in NHWD (n = 185) and HD (n = 92) evaluated in research programs across three institutions: University of California San Diego, University of California Davis, and Columbia University. Only persons with a neuropathologic diagnosis of intermediate/high AD determined by NIA Reagan and/or NIA-AA criteria were included. A frequency-balanced random sampl

SUBMITTER: Scalco R 

PROVIDER: S-EPMC10311731 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature