Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer.

ABSTRACT:

Background

Urothelial bladder cancer is most frequently diagnosed at the non-muscle-invasive stage (NMIBC). However, recurrences and interventions for intermediate and high-risk NMIBC patients impact the quality of life. Biomarkers for patient stratification could help to avoid unnecessary interventions whilst indicating aggressive measures when required.

Methods

In this study, immuno-oncology focused, multiplexed proximity extension assays were utilised to analyse plasma (n = 90) and urine (n = 40) samples from 90 newly-diagnosed and treatment-naïve bladder cancer patients. Public single-cell RNA-sequencing and microarray data from patient tumour tissues and murine OH-BBN-induced urothelial carcinomas were also explored to further corroborate the proteomic findings.

Resu

SUBMITTER: Kerzeli IK 

PROVIDER: S-EPMC10311740 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature