Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition.

ABSTRACT:

Background

The discovery of new anti-melanoma drugs with low side effect is urgently required in the clinic. Recent studies showed that morusin, a flavonoid compound isolated from the root bark of Morus Alba, has the potential to treat multiple types of cancers, including breast cancer, gastric cancer, and prostate cancer. However, the anti-cancer effect of morusin on melanoma cells has not been investigated.

Methods

We analyzed the effects of morusin on the proliferation, cell cycle, apoptosis, cell migration and invasion ability of melanoma cells A375 and MV3, and further explored the effects of morusin on tumor formation of melanoma cell. Finally, the effects of morusin on the proliferation, cycle, apoptosis, migration and invasion of A375 cells after knockdown of p53 wer

SUBMITTER: Liu W 

PROVIDER: S-EPMC10311746 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature