Synergistic antiviral activity of Lactobacillus acidophilus and Glycyrrhiza glabra against Herpes Simplex-1 Virus (HSV-1) and Vesicular Stomatitis Virus (VSV): experimental and In Silico insights.

ABSTRACT:

Background

The emergence of different viral infections calls for the development of new, effective, and safe antiviral drugs. Glycyrrhiza glabra is a well-known herbal remedy possessing antiviral properties.

Objective

The objective of our research was to evaluate the effectiveness of a newly developed combination of the probiotics Lactobacillus acidophilus and G. glabra root extract against two viral models, namely the DNA virus Herpes simplex virus-1 (HSV-1) and the RNA virus Vesicular Stomatitis Virus (VSV), with regards to their antiviral properties.

Methodology

To examine the antiviral impacts of various treatments, we employed the MTT assay and real-time PCR methodology.

Results

The findings of our study indicate that the co-administration of L. acidophilu

SUBMITTER: Elebeedy D 

PROVIDER: S-EPMC10311774 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature