Decreased level of serum NT-proCNP associates with disease severity in COVID-19.

ABSTRACT:

Background

C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if elevated, correlates with disease severity and indicates a poor outcome. It is not yet known whether NT-proCNP also correlates with the clinical outcome of patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the current study, we aimed to determine possible changes in the NT-proCNP levels of patients with coronavirus disease 2019 (COVID-19), with special regard to disease severity and outcome.

Methods

In this retrospective analysis, we

SUBMITTER: Bojti I 

PROVIDER: S-EPMC10311835 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature