Electroacupuncture protective effects after cerebral ischemia are mediated through miR-219a inhibition.

ABSTRACT:

Background

Electroacupuncture (EA) is a complementary and alternative therapy which has shown protective effects on vascular cognitive impairment (VCI). However, the underlying mechanisms are not entirely understood.

Methods

Rat models of VCI were established with cerebral ischemia using occlusion of the middle cerebral artery or bilateral common carotid artery. The brain structure and function imaging were measured through animal MRI. miRNA expression was detected by chip and qPCR. Synaptic functional plasticity was detected using electrophysiological techniques.

Results

This study demonstrated the enhancement of Regional Homogeneity (ReHo) activity of blood oxygen level-dependent (BOLD) signal in the entorhinal cortical (EC) and hippocampus (HIP) in response to EA t

SUBMITTER: Dai Y 

PROVIDER: S-EPMC10311837 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature