MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study.

ABSTRACT:

Background

There are few prospective studies on the correlations between MRI features and whole RNA-sequencing data in breast cancer according to molecular subtypes. The purpose of our study was to explore the association between genetic profiles and MRI phenotypes of breast cancer and to identify imaging markers that influences the prognosis and treatment according to subtypes.

Methods

From June 2017 to August 2018, MRIs of 95 women with invasive breast cancer were prospectively analyzed, using the breast imaging-reporting and data system and texture analysis. Whole RNA obtained from surgical specimens was analyzed using next-generation sequencing. The association between MRI features and gene expression profiles was analyzed in the entire tumor and subtypes. Gene networks,

SUBMITTER: Park AY 

PROVIDER: S-EPMC10311893 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature