Associations between polygenic risk score and covid-19 susceptibility and severity across ethnic groups: UK Biobank analysis.

ABSTRACT:

Background

COVID-19 manifests with huge heterogeneity in susceptibility and severity outcomes. UK Black Asian and Minority Ethnic (BAME) groups have demonstrated disproportionate burdens. Some variability remains unexplained, suggesting potential genetic contribution. Polygenic Risk Scores (PRS) can determine genetic predisposition to disease based on Single Nucleotide Polymorphisms (SNPs) within the genome. COVID-19 PRS analyses within non-European samples are extremely limited. We applied a multi-ethnic PRS to a UK-based cohort to understand genetic contribution to COVID-19 variability.

Methods

We constructed two PRS for susceptibility and severity outcomes based on leading risk-variants from the COVID-19 Host Genetics Initiative. Scores were applied to 447,382 participant

SUBMITTER: Farooqi R 

PROVIDER: S-EPMC10311902 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature