Effects of candesartan on cerebral microvascular function in mild cognitive impairment: Results of two clinical trials.

ABSTRACT:

Background

Cerebral microvascular dysfunction is commonly seen in Alzheimer's disease (AD) and vascular cognitive impairment (VCI). Cerebrovascular reactivity (CVR) to CO₂ reflects cerebral microvascular health and may be modulated by the renin-angiotensin system (RAS). This study aimed to investigate the effects of RAS modulation on CVR in individuals with mild cognitive impairment (MCI) due to underlying vascular or AD etiologies.

Methods

This study presents findings of candesartan's effects on the secondary outcomes of two double-blind randomized clinical trials of 12-month therapy of candesartan versus lisinopril in VCI (CALIBREX (Candesartan vs Lisinopril Effects on the Brain and Endothelial Function in Executive MCI)) and candesartan versus placebo in prodro

SUBMITTER: Henley B 

PROVIDER: S-EPMC10311938 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature