Circling back to PTEN: Fumarate inhibits canonical tumor suppressor.

ABSTRACT: Ge et al. (2022) describes an inhibitory, post-translational modification of PTEN at C211 by fumarate, which offers new insight into the integration of PI3K signaling and metabolism via a potential feedforward regulatory mechanism involving a PI3K-glucose-fumarate-PTEN axis.

SUBMITTER: Claridge SE 

PROVIDER: S-EPMC10311992 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature