The gut microbiome and metabolome in kidney transplant recipients with normal and moderately decreased kidney function.

ABSTRACT:

Background

The kidney transplant recipients (KTRs) were diagnosed with Chronic Kidney Disease after transplantation (CKD-T). CKD-T can be affected by the microbial composition and metabolites. The present study integrates the analysis of gut microbiome and metabolites to further identify the characteristics of CKD-T.

Methods

We collected 100 fecal samples of KTRs and divided them into two groups according to the stage progression of CKD-T. Among them, 55 samples were analyzed by Hiseq sequencing, and 100 samples were used for non-targeted metabolomics analysis. The gut microbiome and metabolomics of KTRs were comprehensively characterized.

Results

As well as significant differences in gut microbiome diversity between the CKD G1-2T group and CKD G3T group. Eight flora

SUBMITTER: Lan Y 

PROVIDER: S-EPMC10312025 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature