Apicidin confers promising therapeutic effect on acute myeloid leukemia cells via increasing QPCT expression.

ABSTRACT: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by abnormal cell proliferation, apoptosis repression and myeloid differentiation blockade of hematopoietic stem/progenitor cells. Developing and identifying novel therapeutic agents to reverse the pathological processes of AML are of great significance. Here in this study, we found that a fungus-derived histone deacetylase inhibitor, Apicidin, presents promising therapeutic effect on AML by inhibiting cell proliferation, facilitating apoptosis and inducing myeloid differentiation of AML cells. Mechanistic investigation revealed that QPCT is identified as a potential downstream target of Apicidin, which exhibits significantly decreased expression in AML samples compared with the normal controls and is remar

SUBMITTER: Liu L 

PROVIDER: S-EPMC10312027 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature