Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients.

ABSTRACT:

Objectives

The network mechanism underlying the initial response to antiseizure medication in epilepsy has not been revealed yet. Given the central role of the thalamus in the brain network, we conducted a case-control study to investigate the association between thalamic connectivity and medication response.

Methods

We recruited 39 patients with newly diagnosed and medication-naïve epilepsy of genetic or unknown etiology, including 26 with a good response (GR group) and 13 with a poor response (PR group), and 26 matched healthy participants (control group). We measured the gray matter density (GMD) and the amplitude of low-frequency fluctuation (ALFF) of bilateral thalami. We then set each thalamus as the seed region of interest (ROI) to calculate voxel-wise functional conn

SUBMITTER: Zhong J 

PROVIDER: S-EPMC10312096 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature