The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.

ABSTRACT:

Background

To address the rising prevalence of Alzheimer's disease and related dementias, effective interventions that can be widely disseminated are warranted. The Preventing Alzheimer's with Cognitive Training study (PACT) investigates a commercially available computerized cognitive training program targeting improved Useful Field of View Training (UFOVT) performance. The primary goal is to test the effectiveness of UFOVT to reduce incidence of clinically defined mild cognitive impairment (MCI) or dementia with a secondary objective to examine if effects are moderated by plasma β-amyloid level or apolipoprotein E e4 (APOE e4) allele status.

Methods/design

This multisite study utilizes a randomized, controlled experimental design with blinded assessors and investigators. In

SUBMITTER: Nicholson JS 

PROVIDER: S-EPMC10312210 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature