ACCURATE CONSTRUCTION OF LONG RANGE HAPLOTYPE IN UNRELATED INDIVIDUALS.

ABSTRACT: Haplotype, or the sequence of alleles along a single chromosome, has important applications in phenotype-genotype association studies, as well as in population genetics analyses. Because haplotype cannot be experimentally assayed in diploid organisms in a high-throughput fashion, numerous statistical methods have been developed to reconstruct probable haplotype from genotype data. These methods focus primarily on accurate phasing of a short genomic region with a small number of markers, and the error rate increases rapidly for longer regions. Here we introduce a new phasing algorithm, emphases, which aims to improve long-range phasing accuracy. Using datasets from multiple populations, we found that emphases reduces long-range phasing errors by up to 50% compared to the current state-of-th

SUBMITTER: Johnson NA 

PROVIDER: S-EPMC10312227 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature