The impact of regional heterogeneity in whole-brain dynamics in the presence of oscillations.

ABSTRACT: Large variability exists across brain regions in health and disease, considering their cellular and molecular composition, connectivity, and function. Large-scale whole-brain models comprising coupled brain regions provide insights into the underlying dynamics that shape complex patterns of spontaneous brain activity. In particular, biophysically grounded mean-field whole-brain models in the asynchronous regime were used to demonstrate the dynamical consequences of including regional variability. Nevertheless, the role of heterogeneities when brain dynamics are supported by synchronous oscillating state, which is a ubiquitous phenomenon in brain, remains poorly understood. Here, we implemented two models capable of presenting oscillatory behavior with different levels of abstraction: a phe

SUBMITTER: Perl YS 

PROVIDER: S-EPMC10312285 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature