A Randomized Controlled Trial to Compare Immunogenicity to Cell-Based Versus Live-Attenuated Influenza Vaccines in Children.

ABSTRACT:

Background

Few studies have focused on the immune response to more recent influenza vaccine formulations such as cell-cultured inactivated influenza vaccine (ccIIV4) or live-attenuated influenza vaccine (LAIV4) in older children and young adults, or differences in immunoglobulin response using newer antibody landscape technology.

Methods

Participants ages 4-21 were randomized to receive ccIIV4 (n = 112) or LAIV4 (n = 118). A novel high-throughput multiplex influenza antibody detection assay was used to provide detailed IgG, IgA, and IgM antibody isotypes, along with hemagglutination inhibition levels (HAI), measured pre- and 28 days post-vaccination.

Results

The HAI and immunoglobulin isotype response to ccIIV4 was greater than LAIV4, with significant increases in IgG

SUBMITTER: Williams KV 

PROVIDER: S-EPMC10312301 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature