Critical role of the ventral temporal lobe in naming.

ABSTRACT:

Objective

Lexical retrieval deficits are characteristic of a variety of different neurological disorders. However, the exact substrates responsible for this are not known. We studied a large cohort of patients undergoing surgery in the dominant temporal lobe for medically intractable epilepsy (n = 95) to localize brain regions that were associated with anomia.

Methods

We performed a multivariate voxel-based lesion-symptom mapping analysis to correlate surgical lesions within the temporal lobe with changes in naming ability. Additionally, we used a surface-based mixed-effects multilevel analysis to estimate group-level broadband gamma activity during naming across a subset of patients with electrocorticographic recordings and integrated these results with lesion-deficit findi

SUBMITTER: Snyder KM 

PROVIDER: S-EPMC10312312 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature