DNA structural properties of DNA binding sites for 21 transcription factors in the mycobacterial genome.

ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis, has evolved over time into a multidrug resistance strain that poses a serious global pandemic health threat. The ability to survive and remain dormant within the host macrophage relies on multiple transcription factors contributing to virulence. To date, very limited structural insights from crystallographic and NMR studies are available for TFs and TF-DNA binding events. Understanding the role of DNA structure in TF binding is critical to deciphering MTB pathogenicity and has yet to be resolved at the genome scale. In this work, we analyzed the compositional and conformational preference of 21 mycobacterial TFs, evident at their DNA binding sites, in local and global scales. Results suggest that most TFs prefer bindin

SUBMITTER: Dey U 

PROVIDER: S-EPMC10312376 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature