The RNA-binding protein, Imp specifies olfactory navigation circuitry and behavior in Drosophila.

ABSTRACT: Complex behaviors depend on the precise developmental specification of neuronal circuits, but the relationship between genetic prograssms for neural development, circuit structure, and behavioral output is often unclear. The central complex (CX) is a conserved sensory-motor integration center in insects that governs many higher order behaviors and largely derives from a small number of Type II neural stem cells. Here, we show that Imp, a conserved IGF-II mRNA-binding protein expressed in Type II neural stem cells, specifies components of CX olfactory navigation circuitry. We show: (1) that multiple components of olfactory navigation circuitry arise from Type II neural stem cells and manipulating Imp expression in Type II neural stem cells alters the number and morphology of many of these c

SUBMITTER: Hamid A 

PROVIDER: S-EPMC10312496 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature