Cyanide-dependent control of terminal oxidase hybridization by Pseudomonas aeruginosa MpaR.

ABSTRACT: Pseudomonas aeruginosa is a common, biofilm-forming pathogen that exhibits complex pathways of redox metabolism. It produces four different types of terminal oxidases for aerobic respiration, and for one of these-the cbb₃-type terminal oxidases-it has the capacity to produce at least 16 isoforms encoded by partially redundant operons. It also produces small-molecule virulence factors that interact with the respiratory chain, including the poison cyanide. Previous studies had indicated a role for cyanide in activating expression of an "orphan" terminal oxidase subunit gene called ccoN4 and that the product contributes to P. aeruginosa cyanide resistance, fitness in biofilms, and virulence-but the mechanisms underlying this process had not been elucidat

SUBMITTER: Smiley MK 

PROVIDER: S-EPMC10312525 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature