Citrate cross-feeding between Pseudomonas aerguinosa genotypes supports lasR mutant fitness.

ABSTRACT: Across the tree of life, clonal populations-from cancer to chronic bacterial infections - frequently give rise to subpopulations with different metabolic phenotypes. Metabolic exchange or cross-feeding between subpopulations can have profound effects on both cell phenotypes and population-level behavior. In Pseudomonas aeruginosa, subpopulations with loss-of-function mutations in the lasR gene are common. Though LasR is often described for its role in density-dependent virulence factor expression, interactions between genotypes suggest potential metabolic differences. The specific metabolic pathways and regulatory genetics enabling such interactions were previously undescribed. Here, we performed an unbiased metabolomics analysis that revealed broad differences in intracellul

SUBMITTER: Mould DL 

PROVIDER: S-EPMC10312601 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature