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NG2 Glia Reprogramming Induces Robust Axonal Regeneration After Spinal Cord Injury.

ABSTRACT: Spinal cord injury (SCI) often leads to neuronal loss, axonal degeneration and behavioral dysfunction. We recently show that in vivo reprogramming of NG2 glia produces new neurons, reduces glial scaring, and ultimately leads to improved function after SCI. By examining endogenous neurons, we here unexpectedly uncover that NG2 glia reprogramming also induces robust axonal regeneration of the corticospinal tract and serotonergic neurons. Such reprogramming-induced axonal regeneration may contribute to the reconstruction of neural networks essential for behavioral recovery.

SUBMITTER: Tai W

PROVIDER: S-EPMC10312714 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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NG2 Glia Reprogramming Induces Robust Axonal Regeneration After Spinal Cord Injury.

Tai Wenjiao W Du Xiaolong X Chen Chen C Xu Xiao-Ming XM Zhang Chun-Li CL Wu Wei W

bioRxiv : the preprint server for biology 20230615

Spinal cord injury (SCI) often leads to neuronal loss, axonal degeneration and behavioral dysfunction. We recently show that in vivo reprogramming of NG2 glia produces new neurons, reduces glial scaring, and ultimately leads to improved function after SCI. By examining endogenous neurons, we here unexpectedly uncover that NG2 glia reprogramming also induces robust axonal regeneration of the corticospinal tract and serotonergic neurons. Such reprogramming-induced axonal regeneration may contribut ...[more]

PMID: 37398355

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NG2 glia reprogramming induces robust axonal regeneration after spinal cord injury.

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