Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research.

ABSTRACT: Lyme disease, caused by an infection with the spirochete Borrelia burgdorferi , is the most common vector-borne disease in North America. B. burgdorferi strains harbor extensive genomic and proteomic variability and further comparison is key to understanding the spirochetes infectivity and biological impacts of identified sequence variants. To achieve this goal, both transcript and mass spectrometry (MS)-based proteomics was applied to assemble peptide datasets of laboratory strains B31, MM1, B31-ML23, infective isolates B31-5A4, B31-A3, and 297, and other public datasets, to provide a publicly available Borrelia PeptideAtlas ( http://www.peptideatlas.org/builds/borrelia/ ). Included is information on total proteome, secretome, and membrane proteome of these B. burgdorferi

SUBMITTER: Reddy PJ 

PROVIDER: S-EPMC10312716 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature