Spindle Chirp and other Sleep Oscillatory Features in Young Children with Autism.

ABSTRACT:

Objectives

To determine whether spindle chirp and other sleep oscillatory features differ in young children with and without autism.

Methods

Automated processing software was used to re-assess an extant set of polysomnograms representing 121 children (91 with autism [ASD], 30 typically-developing [TD]), with an age range of 1.35-8.23 years. Spindle metrics, including chirp, and slow oscillation (SO) characteristics were compared between groups. SO and fast and slow spindle (FS, SS) interactions were also investigated. Secondary analyses were performed assessing behavioural data associations, as well as exploratory cohort comparisons to children with non-autism developmental delay (DD).

Results

Posterior FS and SS chirp was significantly more negative in ASD than TD. B

SUBMITTER: Cumming D 

PROVIDER: S-EPMC10312722 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature