Common molecular signatures between coronavirus infection and Alzheimer's disease reveal targets for drug development.

ABSTRACT: Cognitive decline has been reported as a common consequence of COVID-19, and studies have suggested a link between COVID-19 infection and Alzheimer's disease (AD). However, the molecular mechanisms underlying this association remain unclear. To shed light on this link, we conducted an integrated genomic analysis using a novel Robust Rank Aggregation method to identify common transcriptional signatures of the frontal cortex, a critical area for cognitive function, between individuals with AD and COVID-19. We then performed various analyses, including the KEGG pathway, GO ontology, protein-protein interaction, hub gene, gene-miRNA, and gene-transcription factor interaction analyses to identify molecular components of biological pathways that are associated with AD in the brain also show simi

SUBMITTER: Abyadeh M 

PROVIDER: S-EPMC10312734 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature