Leveraging the Adolescent Brain Cognitive Development Study to improve behavioral prediction from neuroimaging in smaller replication samples.

ABSTRACT: Magnetic resonance imaging (MRI) is a popular and useful non-invasive method to map patterns of brain structure and function to complex human traits. Recently published observations in multiple large scale studies cast doubt upon these prospects, particularly for prediction of cognitive traits from structural and resting state functional MRI, which seems to account for little behavioral variability. We leverage baseline data from thousands of children in the Adolescent Brain Cognitive Development^SM (ABCD^®) Study to inform the replication sample size required with both univariate and multivariate methods across different imaging modalities to detect reproducible brain-behavior associations. We demonstrate that by applying multivariate methods to high-dimensional brain

SUBMITTER: Makowski C 

PROVIDER: S-EPMC10312746 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature