Direct interhemispheric cortical communication via thalamic commissures: a new white-matter pathway in the primate brain.

ABSTRACT: Cortical neurons of eutherian mammals project to the contralateral hemisphere, crossing the midline primarily via the corpus callosum and the anterior, posterior, and hippocampal commissures. We recently reported an additional commissural pathway in rodents, termed the thalamic commissures (TCs), as another interhemispheric axonal fiber pathway that connects cortex to the contralateral thalamus. Here, we demonstrate that TCs also exist in primates and characterize the connectivity of these pathways with high-resolution diffusion-weighted magnetic resonance imaging, viral axonal tracing, and functional MRI. We present evidence of TCs in both New World (Callithrix jacchus and Cebus apella) and Old World primates (Macaca mulatta). Further, like rodents, we show that the T

SUBMITTER: Szczupak D 

PROVIDER: S-EPMC10312754 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature