Different gametogenesis states uniquely impact longevity in Caenorhabditis elegans.

ABSTRACT: Curtailed reproduction affects lifespan and fat metabolism in diverse organisms, suggesting a regulatory axis between these processes. In Caenorhabditis elegans, ablation of germline stem cells (GSCs) leads to extended lifespan and increased fat accumulation, suggesting GSCs emit signals that modulate systemic physiology. Previous studies mainly focused on the germline-less glp-1(e2141) mutant, however, the hermaphroditic germline of C. elegans provides an excellent opportunity to study the impact of different types of germline anomalies on longevity and fat metabolism. In this study, we compared the metabolomic, transcriptomic, and genetic pathway differences in three sterile mutants: germline-less glp-1, feminized fem-3, and masculinized mog-3. W

SUBMITTER: Chaturbedi A 

PROVIDER: S-EPMC10312764 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature