Meta-Analysis of Breast Cancer Risk for Individuals with PALB2 Pathogenic Variants.

ABSTRACT:

Background

Pathogenic variants in cancer susceptibility genes can now be tested efficiently and economically with the wide availability of multi-gene panel testing. This has resulted in an unprecedented rate of identifying individuals carrying pathogenic variants. These carriers need to be counselled about their future cancer risk conferred by the specific gene mutation. An important cancer susceptibility gene is PALB2. Several studies reported risk estimates for breast cancer (BC) associated with pathogenic variants in PALB2. Because of the variety of modalities (age specific risk, odds ratio, relative risk, and standardized incidence ratio) and effect sizes of these risk estimates, a meta-analysis of all of these estimates of BC risk is necessary to provide accurate counseling of

SUBMITTER: Ruberu TLM 

PROVIDER: S-EPMC10312825 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature