Exploring [¹¹C]CPPC as a CSF1R-targeted PET Imaging Marker for Early Parkinson's Disease Severity.

ABSTRACT: Neuroinflammation through enhanced innate immunity is thought play a role in the pathogenesis of Parkinson's disease (PD). Methods for monitoring neuroinflammation in living patients with PD are currently limited to positron emission tomography (PET) ligands that lack specificity in labeling immune cells in the nervous system. The colony stimulating factor 1 receptor (CSF1R) plays a crucial role in microglial function, an important cellular contributor to the nervous system's innate immune response. Using immunologic methods, we show that CSF1R in human brain is colocalized with the microglial marker, ionized calcium binding adaptor molecule 1 (Iba1). In PD, CSF1R immunoreactivity is significantly increased in PD across multiple brain regions, with the largest differences in the midbrain v

SUBMITTER: Mills KA 

PROVIDER: S-EPMC10312881 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature