Mapping the relationship of white matter lesions to depression in multiple sclerosis.

ABSTRACT:

Importance

Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects nearly one million people in the United States. Up to 50% of patients with MS experience depression.

Objective

To investigate how white matter network disruption is related to depression in MS.

Design

Retrospective case-control study of participants who received research-quality 3-tesla neuroimaging as part of MS clinical care from 2010-2018. Analyses were performed from May 1 to September 30, 2022.

Setting

Single-center academic medical specialty MS clinic.

Participants

Participants with MS were identified via the electronic health record (EHR). All participants were diagnosed by an MS specialist and completed research-quality MRI at 3T. After excluding participa

SUBMITTER: Baller EB 

PROVIDER: S-EPMC10312888 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature