Chest computed tomography characteristics of critically ill COVID-19 patients with auto-antibodies against type I interferons.

ABSTRACT:

Purpose

patients with auto-antibodies neutralizing type I interferons (anti-IFN auto-Abs) are at risk of severe forms of coronavirus disease 19 (COVID-19). The chest computed tomography (CT) scan characteristics of critically ill COVID-19 patients harboring these auto-Abs have never been reported.

Methods

Bicentric ancillary study of the ANTICOV study (observational prospective cohort of severe COVID-19 patients admitted to the intensive care unit (ICU) for hypoxemic acute respiratory failure) on chest CT scan characteristics (severity score, parenchymal, pleural, vascular patterns). Anti-IFN auto-Abs were detected using a luciferase neutralization reporting assay. Imaging data were collected through independent blinded reading of two thoracic radiologists of chest CT studie

SUBMITTER: Rapnouil BL 

PROVIDER: S-EPMC10312938 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature