Neuronal Connectivity as a Determinant of Cell Types and Subtypes.

ABSTRACT: Classifications of single neurons at brain-wide scale is a powerful way to characterize the structural and functional organization of a brain. We acquired and standardized a large morphology database of 20,158 mouse neurons, and generated a whole-brain scale potential connectivity map of single neurons based on their dendritic and axonal arbors. With such an anatomy-morphology-connectivity mapping, we defined neuron connectivity types and subtypes (both called "c-types" for simplicity) for neurons in 31 brain regions. We found that neuronal subtypes defined by connectivity in the same regions may share statistically higher correlation in their dendritic and axonal features than neurons having contrary connectivity patterns. Subtypes defined by connectivity show distinct separation with eac

SUBMITTER: Liu L 

PROVIDER: S-EPMC10312949 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature