Genetic Factors Associated with Suicidal Behaviors and Alcohol Use Disorders in an American Indian Population.

ABSTRACT: American Indians (AI) demonstrate the highest rates of both suicidal behaviors (SB) and alcohol use disorders (AUD) among all ethnic groups in the US. Rates of suicide and AUD vary substantially between tribal groups and across different geographical regions, underscoring a need to delineate more specific risk and resilience factors. Using data from over 740 AI living within eight contiguous reservations, we assessed genetic risk factors for SB by investigating: (1) possible genetic overlap with AUD, and (2) impacts of rare and low frequency genomic variants. Suicidal behaviors included lifetime history of suicidal thoughts and acts, including verified suicide deaths, scored using a ranking variable for the SB phenotype (range 0-4). We identified five loci significantly associated with SB

SUBMITTER: Gilder D 

PROVIDER: S-EPMC10312956 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature