A guide to the BRAIN Initiative Cell Census Network data ecosystem.

ABSTRACT: Characterizing cellular diversity at different levels of biological organization and across data modalities is a prerequisite to understanding the function of cell types in the brain. Classification of neurons is also essential to manipulate cell types in controlled ways and to understand their variation and vulnerability in brain disorders. The BRAIN Initiative Cell Census Network (BICCN) is an integrated network of data-generating centers, data archives, and data standards developers, with the goal of systematic multimodal brain cell type profiling and characterization. Emphasis of the BICCN is on the whole mouse brain with demonstration of prototype feasibility for human and nonhuman primate (NHP) brains. Here, we provide a guide to the cellular and spatial approaches employed by the BI

SUBMITTER: Hawrylycz M 

PROVIDER: S-EPMC10313015 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature