Causal relationship between obesity and iron deficiency anemia: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested an association between obesity and iron deficiency anemia, but such studies are susceptible to reverse causation and residual confounding. Here we used Mendelian randomization to assess whether the association might be causal.

Methods

Data on single-nucleotide polymorphisms that might be associated with various anthropometric indicators of obesity were extracted as instrumental variables from genome-wide association studies in the UK Biobank. Data on genetic variants in iron deficiency anemia were extracted from a genome-wide association study dataset within the Biobank. Heterogeneity in the data was assessed using inverse variance-weighted regression, Mendelian randomization Egger regression, and Cochran's Q statistic. Potenti

SUBMITTER: Wang T 

PROVIDER: S-EPMC10313085 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature