Pixel-wise statistical analysis of myocardial injury in STEMI patients with delayed enhancement MRI.

ABSTRACT:

Objectives

Myocardial injury assessment from delayed enhancement magnetic resonance images is routinely limited to global descriptors such as size and transmurality. Statistical tools from computational anatomy can drastically improve this characterization, and refine the assessment of therapeutic procedures aiming at infarct size reduction. Based on these techniques, we propose a new characterization of myocardial injury up to the pixel resolution. We demonstrate it on the imaging data from the Minimalist Immediate Mechanical Intervention randomized clinical trial (MIMI: NCT01360242), which aimed at comparing immediate and delayed stenting in acute ST-Elevation Myocardial Infarction (STEMI) patients.

Methods

We analyzed 123 patients from the MIMI trial (62 ± 12 years, 98 ma

SUBMITTER: Duchateau N 

PROVIDER: S-EPMC10313104 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature