The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model.

ABSTRACT:

Introduction

DNA damage is the main predictor of response to radiation therapy for cancer. Its Q8 quantification and characterization are paramount for treatment optimization, particularly in advanced modalities such as proton and alpha-targeted therapy.

Methods

We present a novel approach called the Microdosimetric Gamma Model (MGM) to address this important issue. The MGM uses the theory of microdosimetry, specifically the mean energy imparted to small sites, as a predictor of DNA damage properties. MGM provides the number of DNA damage sites and their complexity, which were determined using Monte Carlo simulations with the TOPAS-nBio toolkit for monoenergetic protons and alpha particles. Complexity was used together with a illustrative and simplistic repair model to depic

SUBMITTER: Bertolet A 

PROVIDER: S-EPMC10313124 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature