Drug repurposing-a promising approach for patients with angina but non-obstructive coronary artery disease (ANOCA).

ABSTRACT: In today's era of individualized precision medicine drug repurposing represents a promising approach to offer patients fast access to novel treatments. Apart from drug repurposing in cancer treatments, cardiovascular pharmacology is another attractive field for this approach. Patients with angina pectoris without obstructive coronary artery disease (ANOCA) report refractory angina despite standard medications in up to 40% of cases. Drug repurposing also appears to be an auspicious option for this indication. From a pathophysiological point of view ANOCA patients frequently suffer from vasomotor disorders such as coronary spasm and/or impaired microvascular vasodilatation. Consequently, we carefully screened the literature and identified two potential therapeutic targets: the blockade of th

SUBMITTER: McChord J 

PROVIDER: S-EPMC10313125 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature