Levels of Complement Components in Children With Acute COVID-19 or Multisystem Inflammatory Syndrome.

ABSTRACT:

Importance

Multisystem inflammatory syndrome in children (MIS-C) is a severe and unrestrained inflammatory response with multiorgan involvement, which occurs within a few weeks following the resolution of acute SARS-CoV-2 infection. The complement system is a vital part of the innate immune system and plays a role in COVID-19 pathogenesis.

Objective

To examine and compare the levels of complement components and regulators along with complement activation products in the different clinical spectrum of children with SARS-CoV-2 and a control group.

Design, setting, and participants

This cross-sectional study analyzed children with MIS-C admitted to a single hospital in India from June through September 2020. Eligible participants were children who were hospitalized of ei

SUBMITTER: Rajamanickam A 

PROVIDER: S-EPMC10313152 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature